Computer Aided Drug Delivery System

Explain computational modeling of drug disposition in intestinal permeation.

Discuss the importance of experimental design. Write in detail about full factorial design.

Discuss the role of P-glycoprotein receptor inhibition in optimal drug delivery.

Describe with an example how a pharmaceutical formulation can be developed using QbD.

Outline the quality by design concept in pharmaceutical product development with respect to International Council for Harmonisation Guidelines (ICH).

Discuss the bio waiver considerations to be considered to get the exception for In-Vivo studies.

Discuss about artificial intelligence and robotics in pharmaceutical automation and write their application, advantages and disadvantages.

Discuss the optimization parameters and different optimization techniques in formulation development.

Explain in silico modeling of drug disposition by active transport using BBB-choline transporter.

Explain the role of computers in clinical data collection and management.

Mention the significance of statistical modeling in pharmaceutical research and development.

Discuss the differences between descriptive and mechanistic modeling in detail.

Explain different levels of In-vitro and In-vivo correlations.

Discuss the steps involved in the computer-aided formulation development of pharmaceutical emulsions.

Write short notes on any two

Role of Nucleoside transporters.

ICHQ8 Guideline.

Population modeling.

Fed Vs fasted state.