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Total No. of Questions 8]
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Roll No.........
MPH-201T
M.Pharmacy (PCI), II Semester
Examination, June 2022
Molecular Pharmaceutics (Nano Tech and
Targeted DDS)
Time: Three Hours
Maximum Marks : 70
Note:
i) Attempt any five questions.
ii) All questions carry equal marks.
1. a)
Discuss brain specific drug delivery system. Why delivery of drug to brain is a challenge?
b)
Explain drug targeting. What are the ideal characteristics of a carrier?
2. a)
Discuss in detail how nano-particles improve drug delivery?
b)
Explain in detail evaluation methods of intra nasal route delivery system.
3. a)
Discuss the approaches and factors affecting of pulmonary drug delivery system.
b)
Explain principle and techniques of microencapsulation.
4. a)
Explain about two phase and three phase aerosol systems. Explain various filling techniques.
b)
Discuss preparation and immunological properties of monoclonal antibodies.
5. a)
Explain different types of tumor targeting. What are the Limitations of Drug Targeting to Tumor?
b)
Describe the structural components and methods of preparation of liposome's for drug targeting.
6. a)
Discuss advancement in liposomal drug delivery system considering any one example.
b)
Explain gene expression systems. Discuss in detail viral and non-viral gene transfer methods.
7. a)
Explain the principle and techniques of formulating nanoparticles.
b)
Describe in detail method of preparation and characterization of aquasomes.
8. i)
Preparation and application of electrosomes.
ii)
Liposomal gene drug delivery system.
iii)
Gene therapy.
iv)
Aptamers.