Pharmacology

Explain the terms.

1. Synergism
2. Antagonism
3. Idiosyncrasy
4. Iatrogenic disease

Draw single dose bioavailability curve. Discuss the pharmaceutical factors affecting bioavailability of drugs.

Differentiate the following.

1. Sedative and Hypnotic
2. General and Local Anaesthetics

Discuss the pharmacological action and uses of Morphine.

Explain (any two)

1. Dales Vasomotor Reversal and Biphasic response of Adrenaline
2. Atropine is used as a pre-anaesthetic medication
3. Aspirin is not given to patients suffering from peptic ulcer.

Classify Non-opioid analgesics with examples. Discuss the pharmacology and adverse reactions of Aspirin.

Classify epilepsy and antiepileptic agents. Discuss the pharmacology, therapeutic uses and contra indications of Phenytoin.

Differentiate (any two)

1. REM and NREM sleep
2. Miosis and Mydriasis
3. Sympathetic and Parasympathetic nervous system

Classify the Anxiety disorder. Discuss the pharmacological action of Benzodiazepines.

Write short notes on any four.

1. Anti Parkinson drugs
2. Carminatives
3. Vasodilators
4. Cardiotonic agents
5. Antidiuretic drugs
6. Thrombolytic drugs

Explain angina pectoris. Discuss the mechanism of action, pharmacological action and uses of Sorbitrate.

Discuss the life cycle of malarial parasite with diagram.

Write notes on (any two)

1. Bacterial resistance
2. Super infection
3. Combination drug therapy in TB
4. Chemotherapy of cancer

Give the mechanism of action, therapeutic uses and adverse reactions of the following. (any four)

1. Tetracycline
2. Penicillin G
3. Sulphonamide
4. Doxorubicin
5. Bleomycin
6. Streptomycin
7. Rifampicin