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Second Year Pharmacy
PHARMACOLOGY
(ER20-21T)
Note: i) Attempt any five questions.
ii) Each question carry equal marks.
Enlist routes of administration. Write the advantages and disadvantages of Oral Route. 8
Explain the term pharmacokinetics discuss the metabolism of drugs. 8
Explain the following terms: 2×4=8
i) Bioavailability of drugs
ii) Therapeutic index
iii) Protein Binding
iv) First pass effect
Differentiate the following (any two) 2×4=8
i) General and Local Anaesthetic
ii) Sympathetic and Parasympathetic Nerve transmission
iii) Opioid and Non-opioid Analgesics
Discuss the pharmacology and therapeutic uses of Adrenaline or Atropine. 8
Classify Non-opioid analgesics with examples. Discuss the pharmacology and adverse reactions of Aspirin. 8
Classify sedative and Hypnotics with examples. Give the pharmacological action and therapeutic uses of phenobarbitone. 8
Write notes on any two: 2×4=8
i) Stages of General anaesthesia
ii) Mechanism of action of local Anaesthetics
iii) Drugs acting on Eye
iv) Antitussive Agents
Classify Antihypertensive with examples. Give the pharmacology of propranolol. 8
Write notes on any two: 8
i) Mechanism of Action of Digitalis
ii) Antianginal drugs
iii) Fibrinolytic Agents
Classify Diuretics with examples. Give the pharmacology indications and contraindication of loop Diuretics. 8
Write short notes on (Any two) 8
i) Drugs used in Peptic Ulcer
ii) Laxative and Purgatives
iii) Oral Hypoglycemics
Give reasons for the following (Any four) 4×4=16
a) Isosorbide dinitrate is given sublingually.
b) Diuretics are given in combination with antihypertensives.
c) Vitamin C is given with Iron.
d) Probenecid is given with Penicillin.
e) Amoxicillin is given with Clavulanic Acid.
Give the mechanism of action, therapeutic uses and adverse reactions of the following drugs. 8×2=16
a) Erythromycin
b) Gentamicin
c) Cotrimoxazole
d) Rifampicin
e) Chloroquine
f) Amphotericin B
g) Zidovudine
h) Methotrexate