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BP-501T/PY-501 (CBGS)
B.Pharmacy V Semester (PCI Scheme)/
(Non-PCI Scheme)
Examination, November 2023
Choice Based Grading System (CBGS)
Medicinal Chemistry-II
Note: i) Attempt any five questions.
ii) All questions carry equal marks.
iii) In case of any doubt or dispute the English version question should be treated as final.
Write structure and uses of Hydrochlorothiazide and Amiloride. Outline the synthesis and uses of Chlorothiazide.
What are alkylating agents? Write an explanation about alkylating mechanism in anti-cancer therapy. Enumerate the agents used in this category and describe the synthesis and uses of any one of them.
a) What are oral anticoagulants? Write the SAR for Coumarin Derivatives.
b) What is CHF? Detail the Cardiac glycoside with suitable structure.
Write about the Phosphodiesterase-5 (PDE5) inhibitors. Draw the structure and uses of Sildenafil and Tadalafil.
List the structure and uses of the following oral hypoglycemic agents:
a) Biguanides derivative
b) α- Glucosidase inhibitors
Write a brief account of the following:
a) Steroidal nomenclature and stereochemistry
b) Organic nitrates
a) Give the MOA and SAR for local anesthetics.
b) What is HMG-CoA reductase inhibitor? Write the structure and uses of Lovastatin.
Write a short note on following with the suitable chemical structure:
a) Carbonic anhydrase inhibitors
b) Non-sedative antihistamines